Publications

  1. Akhtar S, Smedowski A, Masmali A, Alkanaan A, Khan AA, Almutleb E, Mofty HK, Al-Debasi HI, Samivel R, Almubrad T. Effect of Ultraviolet-A and Riboflavin treatment on the architecture of the center and periphery of normal rat cornea: 7 days post treatment. Exp Eye Res. 2022 Apr 3;219:109064. doi: 10.1016/j.exer.2022.109064.
  2. Pacwa A, Machowicz J, Wojtyniak A, Pietrucha-Dutczak M, Toropainen E, Koskela A, Mrukwa-Kominek E, Lewin-Kowalik J, Smedowski A. SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops. J Inflamm Res. 2022 Feb 8;15:793-806. doi: 10.2147/JIR.S347784. 
  3. Akhtar S, Samivel R, Smedowski A, Alkanaan A, Masmali A, Kirat O, Khan AA, Almubrad T. A unique pre-endothelial layer at the posterior peripheral cornea: ultrastructural study. Sci Rep. 2022 Feb 15;12(1):2556. doi: 10.1038/s41598-022-06552-6. 
  4. Almubrad T, Mencucci R, Smedowski A, Samivel R, Almutleb E, Alkanaan A, Khan AA, Masmali A, Akhtar S. Ultrastructural study of collagen fibrils, proteoglycans and lamellae of the cornea treated with iontophoresis - UVA cross-linking and hypotonic riboflavin solution. Saudi J Biol Sci. 2021 Dec;28(12):7160-7174. doi: 10.1016/j.sjbs.2021.08.019. 
  5. Smedowski A, Akhtar S, Liu X, Pietrucha-Dutczak M, Podracka L, Toropainen E, Alkanaan A, Ruponen M, Urtti A, Varjosalo M, Kaarniranta K, Lewin-Kowalik J. Electrical synapses interconnecting axons revealed in the optic nerve head – a novel model of gap junctions’ involvement in optic nerve function. Acta Ophth. 2019 Oct doi: 10.1111/ aos.14272.
  6. Pietrucha-Dutczak M, Amadio M, Govoni S, Lewin-Kowalik J, Smedowski A. The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration. Front Neurosci. 2018 Nov 15;12:834. doi: 10.3389/fnins.2018.00834. eCollection 2018. Review.
  7. Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14.
  8. Amadio M, Kaarniranta K, Xu H, Smedowski A, Ferrington DA. Molecular Mechanisms Underlying Age-Related Ocular Diseases. Oxid Med Cell Longev. 2018May 21;2018:8476164. doi: 10.1155/2018/8476164. eCollection 2018.
  9. Marchesi N, Thongon N, Pascale A, Provenzani A, Koskela A, Korhonen E, Smedowski A, Govoni S, Kauppinen A, Kaarniranta K, Amadio M. Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways. Med. Cell. Longev. 2018; Vol.2018, ID 4956080, p.1-11.
  10. Smedowski A, Pietrucha-Dutczak M, Maniar R, Ajeleti M, Matuszek I, Lewin-Kowalik J. FluoroGold-labeled organotypic retinal explant culture for neurotoxicity screening studies. Med. Cell. Longev. 2018; Vol.2018, ID 2487473, p.1-11.
  11. Pietrucha-Dutczak M, Smedowski A, Liu X, Matuszek I, Varjosalo M, Lewin-Kowalik J. Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma. Sci Rep. 2017 Nov 6;7(1):14540. doi: 10.1038/s41598-017-14860-5.
  12. Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells – A possible sign of endogenous neuroprotection failure. Biochim Biophys Acta. 2018 Jan;1864(1):296-306.
  13. Trzeciecka A, Paterno JJ, Toropainen E, Koskela A, Podracka L, Korhonen E, Kauppinen A, Kaarniranta K, Smedowski A. Long-term topical application of PF-prostaglandin analogues evokes macrophage infiltration in the ocular adnexa. Eur J Pharmacol. 2016 Jun 9;788:12-20.
  14. Smedowski A, Liu X, Pietrucha-Dutczak M, Matuszek I, Varjosalo M, Lewin-Kowalik J. Predegenerated Schwann cells–a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity. Sci Rep. 2016 Apr 1;6:23187.
  15. Smedowski A, Paterno JJ, Toropainen E, Sinha D, Wylegala E, Kaarniranta K: Excipients of preservative-free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE-2 corneal epithelial cells. J Biochem Pharmacol Res. 2014; 2:175-184.
  16. Pietrucha-Dutczak M, Marcol W, Francuz T, Gołka D, Lewin-Kowalik J. A new protocol for cultivation of predegenerated adult rat Schwann cells. Cell Tissue Bank. 2014 Sep;15(3):403-11.
  17. Smedowski A, Pietrucha-Dutczak M, Kaarniranta K, Lewin-Kowalik J: A rat experimental model of glaucoma incorporating rapid-onset elevation of intraocular pressure. Sci Rep. 2014 Aug 1;4:5910.
  18. Swiech-Sabuda E, Gołka B, Kotulska K, Larysz-Brysz M, Górka D, Gołka D, Marcol W, Lewin-Kowalik J. Do peripheral nerve extracts protect retinal ganglion cells from axotomy-induced death? Restor Neurol Neurosci. 2004;22(1):11-8.
  19. Kotulska K, Lewin-Kowalik J, Jaroslaw-Jerzy B, Larysz-Brysz M, Marcol W, Fus Z. Bcl-2 deficiency deprives peripheral nerves of neurotrophic activity against injured optic nerve. J Neurosci Res. 2003 Sep 15;73(6):846-52.
  20. Gołka B, Lewin-Kowalik J, Swiech-Sabuda E, Larysz-Brysz M, Górka D, Małecka Tendera E. Predegenerated peripheral nerve grafts rescue retinal ganglion cells from axotomy-induced death. Exp Neurol. 2001 Jan;167(1):118-25.